N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinate
10mM in DMSO
Reagent
Code: #157443
Alias
Cabotinib malate; Cabotinib malate; XL184 S-malate; BMS-907351 S-malate
CAS Number
1140909-48-3
science Other reagents with same CAS 1140909-48-3
blur_circular Chemical Specifications
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Molecular Information
Weight
635.60 g/mol
Formula
C₂₈H₂₄FN₃O₅.C₄H₆O₅
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Storage & Handling
Storage
-20℃
description Product Description
Used in pharmaceutical research as a potent inhibitor of receptor tyrosine kinases, particularly targeting pathways involved in cancer cell proliferation and angiogenesis. Demonstrates strong activity in suppressing tumor growth in preclinical models, especially in solid tumors such as lung, breast, and colon cancers. Its structure enables high selectivity and improved pharmacokinetic properties, making it a candidate for targeted cancer therapy development. Also investigated for overcoming resistance to existing kinase inhibitors due to its unique binding mechanism. Currently utilized in experimental studies to evaluate efficacy, safety, and optimal dosing regimens in oncology.
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