7-(But-2-yn-1-yl)-8-((2-hydroxyethyl)amino)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
97%
Reagent
Code: #154800
CAS Number
2074688-84-7
blur_circular Chemical Specifications
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Molecular Information
Weight
433.46 g/mol
Formula
C₂₂H₂₃N₇O₃
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Storage & Handling
Storage
Room temperature
description Product Description
Used as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, in biochemical and cellular research. It is employed to study transcriptional regulation, as CDK9 plays a key role in RNA polymerase II-mediated gene expression. The compound shows utility in cancer research due to its ability to induce apoptosis in tumor cells by disrupting the phosphorylation of key transcriptional regulators. It is also used in combination studies with other anticancer agents to evaluate synergistic effects and overcome drug resistance. Its cell permeability and stability make it suitable for in vitro and in vivo assays targeting kinase-dependent pathways.
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