7-(But-2-yn-1-yl)-8-((2-hydroxyethyl)amino)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
97%
science Other reagents with same CAS 2074688-84-7
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Used as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, in biochemical and cellular research. It is employed to study transcriptional regulation, as CDK9 plays a key role in RNA polymerase II-mediated gene expression. The compound shows utility in cancer research due to its ability to induce apoptosis in tumor cells by disrupting the phosphorylation of key transcriptional regulators. It is also used in combination studies with other anticancer agents to evaluate synergistic effects and overcome drug resistance. Its cell permeability and stability make it suitable for in vitro and in vivo assays targeting kinase-dependent pathways.
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