Used in research as a potent and selective inhibitor of the TRK family of tyrosine kinases, particularly TRKA. It is employed in studies related to neurotrophic signaling and has shown potential in models of pain and neurological disorders where TRK overactivation plays a role. Its high selectivity makes it a valuable tool for dissecting TRK-specific pathways in cellular and animal models. Also utilized in cancer research, especially in tumors driven by TRK fusion proteins, to evaluate therapeutic response and resistance mechanisms.