BAY 11-7082 is widely used in biomedical research for its ability to inhibit NF-κB signaling, a key pathway involved in inflammation, immune responses, and cell survival. It is commonly applied in studies related to inflammatory diseases, where it helps suppress the expression of pro-inflammatory genes. Researchers use it to investigate the role of NF-κB in conditions such as arthritis, sepsis, and inflammatory bowel disease. It is also employed in cancer research to examine how blocking NF-κB affects tumor cell proliferation, apoptosis, and resistance to chemotherapy. BAY 11-7082 has been shown to enhance the effectiveness of certain anti-cancer drugs by sensitizing resistant cancer cells. In addition, it is used in studies of viral infections, as NF-κB activation is often hijacked by viruses for replication. By inhibiting this pathway, BAY 11-7082 helps explore antiviral strategies. Due to its role in modulating cellular stress and apoptosis, it is also utilized in research on neurodegenerative diseases and ischemia-reperfusion injury. Its application remains primarily experimental, serving as a tool compound in cellular and molecular studies.