Brivanib Alaninate (BMS-582664)
10mM in DMSO
Reagent
Code: #142551
CAS Number
649735-63-7
science Other reagents with same CAS 649735-63-7
blur_circular Chemical Specifications
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Molecular Information
Weight
441.46 g/mol
Formula
C₂₂H₂₄FN₅O₄
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Storage & Handling
Storage
-20°C
description Product Description
Used in targeted cancer therapy, particularly in the treatment of hepatocellular carcinoma and colorectal cancer. Acts as a selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) and fibroblast growth factor receptor-1 (FGFR-1), blocking signaling pathways involved in tumor angiogenesis and tumor cell proliferation. By inhibiting these receptors, it helps suppress the formation of new blood vessels that feed tumors and directly hinders cancer cell growth. Has been evaluated in clinical trials both as a monotherapy and in combination with other anticancer agents to improve efficacy in advanced solid tumors. Its dual inhibition mechanism offers potential benefit in tumors resistant to single-pathway inhibitors.
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