Used primarily in research settings as a potent and selective inhibitor of JAK2 (Janus kinase 2), AZ 960 is applied to study signaling pathways involved in hematological malignancies and inflammatory diseases. It demonstrates strong anti-proliferative effects in cancer cell lines dependent on JAK-STAT activation, making it a valuable tool compound for evaluating therapeutic strategies in myeloproliferative disorders and certain leukemias. Its high selectivity helps minimize off-target effects in cellular assays, supporting its use in mechanistic studies and preclinical drug development.