AR-A014418 is a selective inhibitor of glycogen synthase kinase-3 (GSK-3), an enzyme involved in multiple cellular signaling pathways. It is primarily used in research settings to study the role of GSK-3 in processes such as neurodegeneration, inflammation, and insulin signaling. Due to its ability to modulate tau phosphorylation, it has been investigated in models of Alzheimer’s disease to assess potential neuroprotective effects. It also shows utility in studies related to mood disorders and bipolar disease, where GSK-3 activity is implicated in disease mechanisms. Additionally, AR-A014418 has been used to explore cancer cell proliferation, as GSK-3 inhibition can influence Wnt signaling and cell survival pathways. Its selectivity makes it a valuable tool for probing GSK-3-dependent biological functions without significant off-target kinase effects.