VX-11e is primarily utilized in research settings as a potent and selective inhibitor of ERK (extracellular signal-regulated kinase) signaling pathways. It is particularly valuable in studies focused on cancer biology, as ERK signaling plays a critical role in cell proliferation, survival, and differentiation, which are often dysregulated in various cancers. By inhibiting ERK, VX-11e helps researchers understand the mechanisms of tumor growth and evaluate potential therapeutic strategies. Additionally, it is used in preclinical studies to assess its efficacy in combination with other targeted therapies, providing insights into overcoming drug resistance in cancer treatment. Its application extends to investigating other diseases where ERK signaling is implicated, such as inflammatory and autoimmune disorders.