TIE-2/VEGFR-2 kinase-IN-1 is primarily used in research settings to study angiogenesis and tumor growth. It acts as an inhibitor of TIE-2 and VEGFR-2 kinases, which are critical in the formation of blood vessels. By blocking these kinases, it helps researchers understand the mechanisms of vascular development and its role in cancer progression. This compound is valuable in preclinical studies aimed at developing anti-angiogenic therapies for treating cancers and other diseases involving abnormal blood vessel formation. Its application extends to exploring potential treatments for conditions like macular degeneration and diabetic retinopathy, where angiogenesis plays a significant role.