MK-2461 is primarily utilized in cancer research as a potent inhibitor of the c-Met receptor tyrosine kinase. This receptor is often implicated in tumor growth, metastasis, and angiogenesis, making MK-2461 a valuable tool in studying pathways involved in cancer progression. Researchers employ it to investigate the efficacy of targeting c-Met in various cancer models, including lung, gastric, and hepatocellular carcinomas. Additionally, MK-2461 is used in preclinical studies to evaluate its potential as a therapeutic agent, either alone or in combination with other treatments, to enhance anti-tumor activity. Its role in inhibiting c-Met signaling also extends to understanding mechanisms of drug resistance in cancer therapies.