JNK-IN-8 is primarily used in research settings to study the c-Jun N-terminal kinase (JNK) signaling pathway, which plays a critical role in cellular stress responses, apoptosis, and inflammation. It is a selective inhibitor of JNK, making it a valuable tool for investigating the biological functions of this kinase in various disease models, including neurodegenerative disorders, cancer, and inflammatory conditions. Researchers utilize JNK-IN-8 to explore potential therapeutic strategies by modulating JNK activity, as its inhibition has been linked to protective effects in conditions like Alzheimer's disease, Parkinson's disease, and ischemia-reperfusion injury. Additionally, it aids in understanding the molecular mechanisms underlying stress-induced cell death and survival pathways. Its application extends to preclinical studies aimed at developing targeted therapies for diseases where JNK signaling is dysregulated.