PKG inhibitors are primarily used in research and therapeutic contexts to study and modulate cellular signaling pathways. They are particularly valuable in investigating the role of cGMP-dependent protein kinase (PKG) in various physiological processes, such as smooth muscle relaxation, platelet aggregation, and neuronal signaling. In cardiovascular research, PKG inhibitors help explore their potential in managing conditions like pulmonary hypertension and heart failure by targeting specific molecular pathways. Additionally, they are utilized in cancer research to examine their effects on tumor growth and metastasis, as PKG is implicated in cell proliferation and apoptosis. These inhibitors also play a role in studying erectile dysfunction and gastrointestinal motility disorders, providing insights into potential therapeutic interventions.