GSK8612 is primarily used in research settings to study the role of specific biological pathways, particularly those involving kinases. It is a potent and selective inhibitor of TBK1 (TANK-binding kinase 1), a key enzyme involved in immune response and inflammation. Researchers utilize GSK8612 to investigate its effects on autoimmune diseases, cancer, and viral infections, as TBK1 plays a critical role in regulating these processes. By inhibiting TBK1, GSK8612 helps scientists understand the enzyme's function and explore potential therapeutic strategies for conditions where TBK1 activity is dysregulated. Its application is largely confined to preclinical studies, contributing to the development of targeted treatments for complex diseases.