AZD-7648 is primarily investigated for its potential in cancer therapy, particularly as a DNA-dependent protein kinase (DNA-PK) inhibitor. By targeting DNA-PK, it aims to disrupt the DNA repair mechanisms in cancer cells, making them more susceptible to treatments like chemotherapy and radiation. This approach is especially promising in enhancing the efficacy of existing cancer therapies, particularly in tumors that rely on DNA repair pathways for survival. Clinical studies are ongoing to evaluate its safety and effectiveness in combination with other treatments, potentially offering a new strategy for treating resistant or aggressive cancers.