AMG-548 is primarily utilized in research settings to study its effects on p38 MAP kinase, a protein involved in cellular responses to stress and inflammation. It serves as a selective inhibitor, helping scientists understand the role of this kinase in various diseases, such as inflammatory disorders and cancer. By blocking p38 MAP kinase activity, researchers can explore potential therapeutic strategies and develop treatments targeting these conditions. Its application is largely confined to preclinical studies, where it aids in elucidating pathways and mechanisms related to inflammation and cell signaling.