SKIII (SphK-I2) is primarily used in research settings to study the role of sphingosine kinase (SphK) in cellular processes. It is a selective inhibitor of sphingosine kinase 1 (SphK1), an enzyme involved in the production of sphingosine-1-phosphate (S1P), a lipid signaling molecule. By inhibiting SphK1, SKIII helps researchers investigate the pathways and mechanisms related to cell growth, survival, and inflammation. This compound is particularly valuable in studying diseases where SphK1 and S1P play a critical role, such as cancer, autoimmune disorders, and inflammatory conditions. Its application in experimental models provides insights into potential therapeutic targets for these diseases.