XMD8-87 is primarily utilized in biomedical research as a selective inhibitor of the ERK5 (extracellular signal-regulated kinase 5) signaling pathway. Its application is significant in studying cellular processes such as proliferation, differentiation, and survival, particularly in the context of cancer research. By inhibiting ERK5, XMD8-87 helps researchers understand the role of this kinase in tumor growth and metastasis, providing insights into potential therapeutic strategies. Additionally, it is used in pharmacological studies to explore its effects on inflammation and cardiovascular diseases, where ERK5 signaling is implicated. This compound serves as a valuable tool for dissecting molecular mechanisms and developing targeted therapies in various disease models.