Tie2 kinase inhibitors are primarily used in the field of cancer research and treatment. They target the Tie2 receptor, which plays a significant role in angiogenesis, the process of forming new blood vessels. By inhibiting Tie2, these compounds can help reduce the blood supply to tumors, thereby limiting their growth and spread. This makes them a promising option for developing anti-cancer therapies, particularly in cases where tumors are highly dependent on angiogenesis for survival. Additionally, Tie2 inhibitors are being explored for their potential in treating other conditions related to abnormal blood vessel formation, such as certain eye diseases and inflammatory disorders. Research is ongoing to optimize their efficacy and minimize side effects in clinical applications.