SB705498 is primarily utilized in research settings as a potent and selective antagonist for the p38α MAP kinase. Its application is significant in studying inflammatory pathways, as p38α MAP kinase plays a crucial role in the production of pro-inflammatory cytokines. Researchers use this compound to investigate the mechanisms underlying inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and chronic obstructive pulmonary disease (COPD). By inhibiting p38α, SB705498 helps in understanding the potential therapeutic effects of targeting this kinase in reducing inflammation and managing related conditions. Additionally, it is employed in preclinical studies to evaluate the efficacy and safety of p38α inhibitors in various models of inflammation and immune response.