MLN120B is primarily used in research settings to study the role of IKKβ (IκB kinase beta) in various cellular processes, particularly inflammation and immune responses. It acts as a selective inhibitor of IKKβ, which is a key component in the NF-κB signaling pathway. By inhibiting this pathway, MLN120B helps researchers understand the molecular mechanisms underlying inflammatory diseases, such as rheumatoid arthritis, asthma, and certain cancers. Its application extends to preclinical studies aimed at developing targeted therapies for conditions driven by NF-κB activation. Additionally, MLN120B is utilized in biochemical assays to explore the potential of IKKβ inhibition in reducing inflammation and improving therapeutic outcomes.