The hSMG-1 inhibitor 11e is primarily utilized in biomedical research, particularly in the study of cellular mechanisms related to DNA damage response and nonsense-mediated mRNA decay (NMD). It serves as a valuable tool for investigating the role of hSMG-1 kinase in these processes, helping researchers understand its impact on cellular survival and gene regulation. This inhibitor is also explored in cancer research, where it aids in examining potential therapeutic strategies by targeting pathways involved in tumor growth and resistance. Additionally, it contributes to studies on genetic disorders caused by premature termination codons, offering insights into potential treatments.