DYRKs-IN-1 hydrochloride is primarily used in research settings to study the role of dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) in various biological processes. It serves as a potent inhibitor of DYRK1A and DYRK1B, making it valuable for investigating their involvement in cellular functions such as cell cycle regulation, neuronal development, and cancer progression. Researchers utilize this compound to explore its potential therapeutic applications in neurodegenerative diseases, including Alzheimer's and Down syndrome, where DYRK1A dysregulation is implicated. Additionally, it aids in understanding the molecular mechanisms underlying these conditions and in the development of targeted therapies. Its application extends to studying diabetes and other disorders linked to DYRK activity.