2',4',5'-Trifluoroacetophenone
99%
Reagent
Code: #239994
Alias
1-acetyl-2,4,5-trifluorobenzene
CAS Number
129322-83-4
blur_circular Chemical Specifications
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Molecular Information
Weight
174.12 g/mol
Formula
F₃C₆H₂COCH₃
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Registry Numbers
MDL Number
MFCD00061193
thermostat
Physical Properties
Melting Point
-7
Boiling Point
76 °C
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Storage & Handling
Density
1.331 g/mL at 25 °C(lit.)
Storage
Room temperature
description Product Description
Used as an intermediate in the synthesis of pharmaceuticals, particularly in the development of fluorinated drug compounds where the 2,4,5-trifluorophenyl group enhances metabolic stability, lipophilicity, and bioavailability. Commonly employed in the production of anti-inflammatory agents, central nervous system (CNS) active drugs, and antivirals due to its ability to improve membrane permeability and biological activity. Also utilized in agrochemical synthesis for creating herbicides and pesticides with enhanced target specificity and environmental persistence. The ketone moiety serves as a versatile electrophile in various carbon-carbon and carbon-heteroatom bond-forming reactions, such as aldol condensations and nucleophilic additions, in fine chemical manufacturing.
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