JIP-1(153-163) is primarily used in biochemical research to study cellular signaling pathways, particularly those involving the JNK (c-Jun N-terminal kinase) cascade. It serves as a peptide inhibitor, helping researchers understand the role of JNK in processes like apoptosis, stress response, and cell differentiation. This peptide is also utilized in neuroscience studies to explore its effects on neuronal survival and synaptic plasticity. Additionally, it aids in developing therapeutic strategies for diseases linked to JNK dysregulation, such as neurodegenerative disorders and cancer. Its application extends to drug discovery, where it is used to screen and design compounds targeting JNK-related pathways.