IRE1α kinase-IN-6 is primarily used in research settings to study the unfolded protein response (UPR) pathway, which is crucial for cellular stress management. By inhibiting IRE1α kinase activity, this compound helps scientists understand the role of IRE1α in diseases like cancer, diabetes, and neurodegenerative disorders. It is particularly valuable in exploring potential therapeutic strategies targeting ER stress-related conditions. Additionally, it aids in dissecting the molecular mechanisms of cell survival and apoptosis, providing insights into drug development for stress-associated pathologies.