ISRIB (trans-isomer) is primarily used in research to study and modulate the integrated stress response (ISR) pathway in cells. It has shown potential in enhancing cognitive function and memory recovery in preclinical studies, particularly in models of traumatic brain injury and neurodegenerative diseases like Alzheimer's. Additionally, ISRIB is being explored for its ability to improve protein synthesis and cell survival under stress conditions, making it a promising candidate for therapeutic applications in conditions involving cellular stress and impaired translation. Its role in reducing the effects of aging on cognitive decline is also under investigation.