Curcumin-d6 is widely used as an internal standard in analytical chemistry, particularly in mass spectrometry, for the quantification of curcumin and its metabolites in biological samples. Its deuterated structure ensures minimal interference with the analysis, providing accurate and reliable results. It is also employed in pharmacokinetic studies to track the absorption, distribution, metabolism, and excretion of curcumin in vivo. Additionally, Curcumin-d6 aids in research focused on the therapeutic effects of curcumin, such as its anti-inflammatory, antioxidant, and anticancer properties, by enabling precise measurement of curcumin levels in experimental models.