Used in pharmaceutical research as a key intermediate in the synthesis of bioactive compounds targeting neurological disorders. Shows potential in the development of selective enzyme inhibitors, particularly for proteases involved in neurodegenerative disease pathways. Also employed in structure-activity relationship (SAR) studies to optimize drug candidates due to its rigid tetrahydroisoquinoline scaffold and modifiable amide and sulfonamide functional groups. Its fluorinated aryl group enhances binding affinity and metabolic stability in central nervous system-targeted therapeutics.