Poly(vinylbenzyl chloride) is widely used in the production of ion-exchange resins, which are essential for water purification, chemical separation, and catalysis. Its reactive benzyl chloride groups allow for functionalization, making it a key material in the synthesis of anion-exchange resins used in demineralization processes.

In the field of biotechnology, it serves as a precursor for immobilizing enzymes or proteins, enabling their use in biosensors and bioreactors. Additionally, it is employed in the creation of polymer-supported reagents and catalysts, which are crucial in organic synthesis for facilitating reactions and simplifying purification steps.

Its application extends to the development of functional coatings and adhesives, where it enhances bonding properties and durability. The material is also utilized in the preparation of microspheres and nanoparticles for drug delivery systems, offering controlled release and targeted therapy in medical applications.