APETx2 is primarily used in research to study the function of acid-sensing ion channels (ASICs), particularly ASIC3, which plays a role in pain perception and inflammatory responses. It is a valuable tool in neuroscience for understanding the mechanisms of pain and developing potential therapeutic targets for pain management. Additionally, APETx2 is utilized in electrophysiological studies to investigate the role of ASIC3 in various physiological and pathological conditions, such as ischemia and acidosis-related diseases. Its specificity for ASIC3 makes it a crucial compound for dissecting the contributions of this channel in cellular signaling and disease processes.