Diiodotriphenylphosphorane is a versatile reagent in organic synthesis, primarily used for the iodination of alcohols to alkyl iodides under mild conditions. It also acts as a powerful dehydrating agent, particularly in the conversion of alcohols to alkenes, and in the preparation of aromatic and heteroaromatic compounds. Additionally, it is employed in the synthesis of strained ring systems and in palladium-catalyzed coupling reactions where iodine sources are beneficial. Its ability to function as both an iodinating and phosphorus-containing reagent makes it valuable for constructing carbon–carbon and carbon–heteroatom bonds. Commonly applied in pharmaceutical and agrochemical research for building complex molecular frameworks.