Monocrotophos is widely used in agriculture as an effective insecticide for controlling a variety of pests. It is particularly effective against sucking insects, mites, and caterpillars that infest crops such as cotton, rice, sugarcane, and soybeans. The chemical works by inhibiting the activity of acetylcholinesterase, an enzyme essential for nerve function in insects, leading to their paralysis and eventual death.

In addition to its use in crop protection, monocrotophos is also applied in forestry to manage pest infestations that threaten tree health. Its systemic nature allows it to be absorbed by plants, providing long-lasting protection as it moves through the plant tissues.

However, due to its high toxicity to non-target organisms, including humans, birds, and aquatic life, the use of monocrotophos is strictly regulated in many countries. Proper safety measures, such as protective clothing and adherence to application guidelines, are essential to minimize risks to applicators and the environment. Its application is often restricted to specific crops and regions, with alternatives being encouraged to reduce ecological and health hazards.