Niclofolan is primarily used as an acaricide and insecticide in agricultural settings. It is effective against a range of mite species that infest crops, particularly in orchards and vineyards. Its mode of action disrupts the nervous system of mites, leading to paralysis and death, making it useful for controlling resistant populations. Due to its foliar application and systemic properties, Niclofolan provides both immediate and residual protection. It is often applied during growing seasons to prevent mite outbreaks that can damage leaves, fruits, and overall plant health. Its use is especially valuable in integrated pest management programs where selective control with minimal impact on beneficial insects is required.