Used in calibration of ion-selective electrodes for accurate measurement of fluoride concentration in water, beverages, and industrial samples. Essential in environmental testing to monitor fluoride levels in drinking water to ensure compliance with safety regulations. Widely applied in pharmaceutical and dental product quality control to verify fluoride content in toothpastes and mouth rinses. Supports research in geochemistry and hydrology by providing reference values for fluoride in natural water systems. Also used in clinical labs to analyze fluoride in biological samples such as urine and serum for toxicity studies.