FR 167653 free base is primarily utilized in research settings for its role as a selective inhibitor of p38 MAP kinase. This enzyme is involved in the regulation of inflammatory responses, making FR 167653 valuable in studies focused on understanding and controlling inflammation. Researchers employ it to investigate the pathways and mechanisms underlying inflammatory diseases, such as arthritis, sepsis, and other conditions where p38 MAP kinase plays a critical role. Its application extends to preclinical models, where it helps in evaluating potential therapeutic strategies targeting inflammation and immune responses.