GSK2193874 is a potent and selective TRPV4 channel antagonist primarily used in research settings to investigate its effects on ion channel modulation and related biological pathways. It has been explored for its potential in inhibiting TRPV4-mediated calcium influx, which is implicated in various diseases. Researchers are particularly interested in its applications for understanding and potentially treating respiratory conditions such as chronic obstructive pulmonary disease (COPD) and asthma, as well as inflammation, cardiovascular, and metabolic disorders. Its mechanism of action positions it as a valuable tool in preclinical studies for developing novel therapeutic strategies. Additionally, it serves as a reference compound in pharmacological assays to assess the efficacy and safety of related candidates.