MK-886 is primarily used as a potent inhibitor of 5-lipoxygenase-activating protein (FLAP), which plays a key role in the biosynthesis of leukotrienes. Leukotrienes are inflammatory mediators involved in conditions such as asthma, allergic rhinitis, and other inflammatory diseases. By blocking FLAP, MK-886 effectively reduces the production of these mediators, making it a valuable tool in research focused on inflammation and immune response pathways. It is widely used in laboratory studies to investigate the role of leukotrienes in cellular models and animal studies of inflammation, atherosclerosis, and cancer. Researchers also explore its potential in modulating tumor growth and enhancing the sensitivity of certain cancer cells to chemotherapy, particularly in prostate and colon cancer models. Due to its specific mechanism, MK-886 helps in understanding signaling pathways related to oxidative stress and inflammation without directly acting as an antioxidant.