H-151 is primarily used as a selective inhibitor of the STING (Stimulator of Interferon Genes) pathway, making it a valuable tool in immunological research. It is commonly applied in studies involving innate immune responses, particularly to suppress aberrant activation of type I interferon signaling. This compound is utilized in cellular and animal models to investigate autoimmune and inflammatory diseases such as lupus, Aicardi-Goutières syndrome, and other conditions linked to STING hyperactivity. Due to its ability to modulate inflammatory pathways, H-151 also supports research into potential therapeutic strategies for chronic inflammation and immune-related disorders. Its application extends to cancer research, where controlling STING activity can influence the tumor microenvironment and response to immunotherapies.