IL-1R antagonist is widely used in the treatment of autoimmune and inflammatory conditions. It is particularly effective in managing rheumatoid arthritis by blocking the activity of interleukin-1 (IL-1), a cytokine that promotes inflammation and joint damage. This helps reduce pain, swelling, and stiffness in patients. Additionally, it is used in treating cryopyrin-associated periodic syndromes (CAPS), a group of rare genetic disorders characterized by excessive inflammation. In neonatal-onset multisystem inflammatory disease (NOMID), it helps control systemic inflammation and prevent organ damage. The antagonist is also being explored for its potential in treating other inflammatory diseases, such as gout and type 2 diabetes, where IL-1 plays a key role in disease progression. Its ability to modulate the immune response makes it a valuable therapeutic option in various inflammatory and autoimmune conditions.