Used as an intermediate in organic synthesis, particularly in the preparation of indole-based compounds with pharmaceutical relevance. It serves as an acylating agent to introduce the 1-(phenylsulfonyl)indole-2-carbonyl moiety into amines or alcohols, forming amides or esters. These derivatives are often explored in medicinal chemistry for their potential biological activity, including kinase inhibition or anti-inflammatory properties. Its sulfonyl group enhances stability and influences electronic properties, making it valuable in the development of bioactive molecules and heterocyclic compounds.