(1-(tert-Butyldimethylsilyl)-1H-indol-4-yl)boronic acid
≥98%
Reagent
Code: #192502
CAS Number
351457-64-2
blur_circular Chemical Specifications
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Molecular Information
Weight
275.23 g/mol
Formula
C₁₄H₂₂BNO₂Si
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Registry Numbers
MDL Number
MFCD08436007
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Physical Properties
Melting Point
130-135 °C
Boiling Point
352.1±48.0 °C(Predicted)
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Storage & Handling
Density
1.01±0.1 g/cm3(Predicted)
Storage
-20°C, Sealed, Inert Gas
description Product Description
Used primarily as a building block in organic synthesis, especially in Suzuki-Miyaura cross-coupling reactions. It enables the formation of biaryl compounds by coupling with aryl halides, making it valuable in pharmaceutical and agrochemical research. The indole scaffold is common in bioactive molecules, and the presence of the boronic acid group allows for efficient carbon-carbon bond formation. The tert-butyldimethylsilyl (TBS) protecting group stabilizes the indole nitrogen during reactions, ensuring selectivity and compatibility with multi-step synthetic sequences. Commonly employed in the development of drug candidates targeting neurological disorders, inflammation, and cancer.
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