tert-Butyl 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate

95%

Reagent Code: #192369
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CAS Number 1443377-15-8

science Other reagents with same CAS 1443377-15-8

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 361.22 g/mol
Formula C₁₉H₂₅BFNO₄
badge Registry Numbers
MDL Number MFCD28717131
thermostat Physical Properties
Boiling Point 457.4±48.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.13±0.1 g/cm3(Predicted)
Storage -20°C, Sealed, Inert Gas

description Product Description

Used as an intermediate in palladium-catalyzed cross-coupling reactions, particularly in the synthesis of biologically active indole derivatives. The boronate ester group enables Suzuki-Miyaura coupling, allowing the introduction of various aryl or heteroaryl groups at the 2-position of the indole ring. The tert-butyl carbamate (Boc) group protects the indole nitrogen during reactions and can be removed under mild acidic conditions when needed. This compound is valuable in medicinal chemistry for constructing complex molecules, especially in the development of pharmaceuticals targeting neurological disorders, inflammation, and cancer. Its fluorinated indole core enhances binding selectivity and metabolic stability in final drug candidates.

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Size Availability Unit Price Quantity
inventory 1g
10-20 days ฿3,940.00
inventory 5g
10-20 days ฿14,880.00

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tert-Butyl 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
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Used as an intermediate in palladium-catalyzed cross-coupling reactions, particularly in the synthesis of biologically active indole derivatives. The boronate ester group enables Suzuki-Miyaura coupling, allowing the introduction of various aryl or heteroaryl groups at the 2-position of the indole ring. The tert-butyl carbamate (Boc) group protects the indole nitrogen during reactions and can be removed under mild acidic conditions when needed. This compound is valuable in medicinal chemistry for constructing complex molecules, especially in the development of pharmaceuticals targeting neurological disorders, inflammation, and cancer. Its fluorinated indole core enhances binding selectivity and metabolic stability in final drug candidates.
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