tert-Butyl 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
95%
Reagent
Code: #192369
CAS Number
1443377-15-8
science Other reagents with same CAS 1443377-15-8
blur_circular Chemical Specifications
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Molecular Information
Weight
361.22 g/mol
Formula
C₁₉H₂₅BFNO₄
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Registry Numbers
MDL Number
MFCD28717131
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Physical Properties
Boiling Point
457.4±48.0 °C(Predicted)
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Storage & Handling
Density
1.13±0.1 g/cm3(Predicted)
Storage
-20°C, Sealed, Inert Gas
description Product Description
Used as an intermediate in palladium-catalyzed cross-coupling reactions, particularly in the synthesis of biologically active indole derivatives. The boronate ester group enables Suzuki-Miyaura coupling, allowing the introduction of various aryl or heteroaryl groups at the 2-position of the indole ring. The tert-butyl carbamate (Boc) group protects the indole nitrogen during reactions and can be removed under mild acidic conditions when needed. This compound is valuable in medicinal chemistry for constructing complex molecules, especially in the development of pharmaceuticals targeting neurological disorders, inflammation, and cancer. Its fluorinated indole core enhances binding selectivity and metabolic stability in final drug candidates.
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