Used in organic synthesis as an intermediate for pharmaceuticals and bioactive compounds. The iodo group allows for cross-coupling reactions, such as Suzuki or Heck reactions, enabling the introduction of aromatic or alkenyl substituents. Commonly employed in the development of serotonin receptor ligands and other neuroactive agents due to the indole core’s presence in many natural neurotransmitters. Also utilized in the preparation of fluorescent probes and dyes, where the iodine atom can be replaced or used to modulate electronic properties. Its methyl group enhances lipophilicity, aiding in cell membrane permeability for drug design applications.