Voclosporin is primarily used in the treatment of autoimmune diseases, particularly lupus nephritis, a severe form of lupus that affects the kidneys. It works by inhibiting calcineurin, an enzyme that plays a crucial role in activating T-cells, which are involved in the immune response. By suppressing T-cell activation, voclosporin helps reduce inflammation and prevent further damage to the kidneys. This makes it a valuable therapeutic option for patients with lupus nephritis, often used in combination with other immunosuppressive therapies to improve outcomes and slow disease progression. Its targeted mechanism of action offers a more precise approach to managing autoimmune conditions compared to broader immunosuppressants.