Imiquimod hydrochloride is widely used in dermatology for the treatment of certain skin conditions. It is particularly effective in managing external genital and perianal warts caused by the human papillomavirus (HPV). The compound works by stimulating the immune system to attack the warts, leading to their reduction or elimination.

Additionally, it is applied in the treatment of actinic keratosis, a precancerous skin condition caused by prolonged sun exposure. By promoting an immune response, it helps in clearing the abnormal skin cells, reducing the risk of progression to skin cancer.

Imiquimod hydrochloride is also used for superficial basal cell carcinoma, a common type of skin cancer. It aids in the destruction of cancer cells by enhancing local immune activity. Its immunomodulatory properties make it a valuable option in various dermatological therapies.