Leukadherin-1 is primarily used in biomedical research to study cell adhesion and immune responses. It activates CD11b/CD18 integrin (also known as Mac-1), a receptor found on the surface of leukocytes, promoting cell adhesion to surfaces and other cells. This property makes it a valuable tool for investigating leukocyte migration, phagocytosis, and inflammation processes. Researchers use Leukadherin-1 to modulate immune cell behavior in vitro and in animal models, particularly in studies related to acute and chronic inflammation, infection, and autoimmune diseases. It has also been explored for its potential to enhance bacterial clearance by boosting macrophage and neutrophil activity. Additionally, due to its role in promoting resolution of inflammation without causing excessive immune activation, it is being studied for therapeutic applications in sepsis and other inflammatory conditions.