Liarozole dihydrochloride is primarily used in the treatment of certain skin conditions, particularly those related to abnormal cell growth and differentiation. It has been studied for its effectiveness in managing ichthyosis, a group of skin disorders characterized by dry, thickened, and scaly skin. The compound works by modulating retinoic acid metabolism, which helps normalize skin cell turnover and improve skin texture.

Additionally, it has been explored for its potential in treating acne and psoriasis, as it influences the pathways involved in skin cell proliferation and inflammation. In some cases, it has also been investigated for its role in cancer therapy, particularly in cancers where retinoic acid pathways are dysregulated. Its ability to regulate these pathways makes it a promising candidate for further research in dermatology and oncology.