O-(2-Methoxyethyl)hydroxylamine hydrochloride is primarily used in organic synthesis as a reagent for the modification of carbonyl compounds. It is particularly effective in the formation of oxime derivatives, which are valuable intermediates in the synthesis of various pharmaceuticals and agrochemicals. The compound is also employed in the protection of aldehydes and ketones, allowing for selective reactions in complex molecular structures. Additionally, it finds application in the development of bio-conjugates and in the study of protein interactions, where it aids in the labeling and detection of specific biomolecules. Its versatility in chemical transformations makes it a useful tool in both academic research and industrial processes.