Polyethylene oxide is widely used in the pharmaceutical industry as a binder, lubricant, and film-forming agent in tablet formulations. It helps control the release of active ingredients, making it valuable in sustained-release and controlled-release drug delivery systems. In the cosmetics industry, it serves as a thickening agent and stabilizer in creams, lotions, and gels, enhancing texture and consistency. It is also used as a thickener in cleaning products due to its water solubility and non-toxicity.

In industrial applications, it is utilized as a flocculant in water treatment processes to aggregate and remove suspended particles, improving water clarity. It also acts as a lubricant in various manufacturing processes, reducing friction and wear. Additionally, polyethylene oxide is employed in the production of hydrogels for medical applications, such as wound dressings and contact lenses, due to its water-absorbing properties and biocompatibility. In the paper industry, it is used to enhance strength and smoothness during production. It serves as a component in biodegradable films.

In the field of research, it is used as a model polymer for studying rheological properties and polymer behavior in solutions. Its versatility and adaptability make it a valuable material across multiple industries.