2-Chloroacetohydrazide hydrochloride (1:1) is primarily utilized in organic synthesis as a key intermediate for the preparation of various hydrazide derivatives. It is often employed in the development of pharmaceutical compounds, particularly in the synthesis of antitubercular and antimicrobial agents. The compound’s reactive chloro and hydrazide groups make it suitable for constructing complex molecular structures. Additionally, it is used in the synthesis of heterocyclic compounds, which have applications in medicinal chemistry and drug discovery. Its role in facilitating the formation of hydrazone linkages also makes it valuable in the design of bioactive molecules and chemical probes.